1S-LSD (1-(trimethylsilyl)propionyl-lysergic acid diethylamide), nicknamed “Stannum” (Latin for tin, a nod to its silicon-containing structure), is the latest psychedelic lysergamide to enter the market. Like its predecessors (1P, 1cP, 1V, and 1D-LSD), it is a prodrug that the body converts into active LSD-25.
The 225 mcg pellet is specifically dosed to provide a full, high-intensity psychedelic experience, compensating for the additional molecular weight of the 1S-attachment.
Potency and Equivalence
In the world of lysergamide analogs, the larger the “pendant” group attached to the molecule, the more raw weight is needed to deliver a standard dose of LSD to the brain.
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Equivalence: A 225 mcg pellet of 1S-LSD is roughly equivalent to 150 mcg of pure LSD-25.
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Intensity: This is considered a strong dose. While 100 mcg is the “standard” recreational hit, 150 mcg (effective) pushes the user into a space of significant visual distortion and potential ego dissolution.
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Metabolism: The silicon-based “1S” group is designed to be cleaved off by the body’s enzymes. Early user reports and 2025-2026 data suggest the onset is relatively fast, often felt within 30 to 60 minutes, which is quicker than the older 1V-LSD (“Valerie”).




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